Transformation of Chenodeoxycholic Acid and Ursodeoxycholic Acid by Human Intestinal Bacteria
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چکیده
منابع مشابه
Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by human intestinal lec
Six strains of lecithinase-lipase-negative Clostridia, isolated from human feces, were capable of oxidizing chenodeoxycholic acid to 3a-hydroxy-7-keto-5P-cholanoic acid and of epimerizing it to ursodeoxycholic acid. The identity of the reaction products was confirmed by coniparing their mass spectra, obtained by combined gas-liquid chromatography-mass spectrometry, with those of authentic refer...
متن کاملEpimerization of chenodeoxycholic acid to ursodeoxycholic acid by human intestinal lecithinase-lipase-negative Clostridia.
Six strains of lecithinase-lipase-negative Clostridia, isolated from human feces, were capable of oxidizing chenodeoxycholic acid to 3 alpha-hydroxy-7 keto-5 beta-cholanoic acid and of epimerizing it to ursodeoxycholic acid. The identity of the reaction products was confirmed by comparing their mass spectra, obtained by combined gas-liquid chromatography-mass spectrometry, with those of authent...
متن کاملUrsodeoxycholic acid, chenodeoxycholic acid, and 7-ketolithocholic acid are primary bile acids of the guinea pig.
Guinea pig gallbladder bile contains chenodeoxycholic acid (62 +/- 5%), ursodeoxycholic acid (8 +/- 5%), and 7-ketolithocholic acid (30 +/- 5%). All three bile acids became labeled to the same specific activity within 30 min after [3H]cholesterol was injected into bile fistula guinea pigs. When a mixture of [3H]ursodeoxycholic acid and [14C]chenodeoxycholic acid was infused into another bile fi...
متن کاملDirect measurement of hepatic extraction of chenodeoxycholic acid and ursodeoxycholic acid in man.
1. The hepatic extraction ratios of chenodeoxycholic acid and ursodeoxycholic acid have been measured in 12 patients without, and 20 patients with, liver disease. 2. Ten of the patients without liver disease were studied during cardiac catheterization, with a continuous infusion technique. Two of the patients without liver disease and all those with liver disease received an intravenous bolus o...
متن کاملIncreased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.
The formation of ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, was investigated in three subjects with cerebrotendinous xanthomatosis and in four subjects with gallstones. Total biliary bile acid composition was analyzed by gas-liquid chromatography before and after 4 months of treatment with 0.75 g/day of chenodeoxycholic acid. Individual bile acids were identified ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1979
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(79)80079-7